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Tumor Response After [90Y-DOTA0,Tyr3]Octreotide Radionuclide Therapy in a Transplantable Rat Tumor Model Is Dependent on Tumor Size

Marion de Jong, Wout A.P. Breeman, Bert F. Bernard, Willem H. Bakker, Theo J. Visser, Peter P.M. Kooij, Arthur van Gameren and Eric P. Krenning

Departments of Nuclear Medicine and Internal Medicine III, University Hospital and Erasmus University Rotterdam, Rotterdam, The Netherlands



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  		FIGURE 1. Structures of octreotide, [Tyr3]octreotide, and DOTA.

 


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  		FIGURE 2. Survival curves of rats bearing small (<=1 cm2; solid line) vs. large (>=10 cm2; dashed line) CA20948 tumors after no administration (control) or 111 MBq [90Y-DOTA0,Tyr3]octreotide administration. For all groups, n = 8.

 


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  		FIGURE 3. Tumor responses found in rats bearing small (<=1 cm2) vs. large (>=10 cm2) CA20948 tumors after no administration (control) or 111 MBq [90Y-DOTA0,Tyr3]octreotide administration. NR = no response; PR = partial response; CR = complete response. For all groups, n = 8.

 


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  		FIGURE 4. Tumor responses found in rats bearing very small (<=0.1 cm2; n = 10), small (<=1 cm2; n = 8), medium (3–9 cm2; n = 7), or large (>=14 cm2; n = 8) CA20948 tumors after 370 MBq [90Y-DOTA0,Tyr3]octreotide administration. PR = partial response; CR = complete response.

 


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  		FIGURE 5. Survival curves of rats bearing very small (<=0.1 cm2; n = 10), small (<=1 cm2; n = 8), medium (3–9 cm2; n = 7), or large (>=14 cm2; n = 8) CA20948 tumors after 370 MBq [90Y-DOTA0,Tyr3]octreotide administration.

 


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  		FIGURE 6. Tumor volumes (3–9 cm2 at onset of therapy on day 24) in rats as function of time after implantation and injection of 370 MBq [90Y-DOTA0,Tyr3]octreotide at 24 d after implantation (n = 7).

 




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