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Validation of Myocardial Perfusion Reserve Measurements Using Regularized Factor Images of H215O Dynamic PET Scans

Frédérique Frouin, Pascal Merlet, Yassine Bouchareb, Vincent Frouin, Jean-Luc Dubois-Randé, Alain De Cesare, Alain Herment, André Syrota and Andrew Todd-Pokropek

Unité 494, Imagerie Médicale Quantitative, Institut National de la Santé et de la Recherche Médicale, Paris; Service Hospitalier Frédéric Joliot, Département de Recherche Médicale, Direction des Sciences du Vivant, Commissariat à l’Energie Atomique, Orsay; Services de Cardiologie et de Médecine Nucléaire, Centre Hospitalo-Universitaire Henri Mondor, Université Paris XII, Créteil, France; and Department of Medical Physics and Bioengineering, University College London, London, England



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FIGURE 1. Three factors (A) and factor images (B) obtained on 4 consecutive slices for patient with idiopathic dilated cardiomyopathy. First row shows right cavities, second row shows left cavities, and third row shows myocardium and other tissues.

 


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FIGURE 2. RFIs obtained for same patient as in Figure 1, with same layout.

 


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FIGURE 3. Three-color representation of RFIs (blue for right cavities, red for left cavities, and green for myocardium and other tissues) used for manual delimitation of left ventricle and myocardial ROIs.

 


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FIGURE 4. Correlation of MPR using either FDG study (A) or H215O RFI (first operator, B; second operator, C) with CFR using intracoronary Doppler technique.

 


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FIGURE 5. Bland–Altman representation of MPR using either FDG study (A) or H215O RFIs (B) with CFR using intracoronary Doppler technique.

 


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FIGURE 6. Correlation of MPR obtained from H215O RFIs with MPR obtained from FDG scan.

 





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