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Imaging of Striatal Dopamine D2 Receptors with a PET System for Small Laboratory Animals in Comparison with Storage Phosphor Autoradiography: A Validation Study with 18F-(N-Methyl)Benperidol

Susanne Nikolaus, Rolf Larisch, Markus Beu, Henning Vosberg and Hans-Wilhelm Müller-Gärtner

Department of Nuclear Medicine, Heinrich-Heine-Universität, Düsseldorf, Germany



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  		FIGURE 1. Transverse slices of Sprague–Dawley rat head obtained with PET camera (A) and taken from digital 3D stereotactic atlas by Toga et al. (26) (B) show accordance of PET image and macroanatomy of rat head. Highest concentrations of 18F-(N-methyl)benperidol are found in striata (1) and in Harder’s glands (2). For dorsoventral positions in cryosection image, see Toga et al. (26).

 


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  		FIGURE 2. Characteristic images (coronal sections) obtained with PET (A) and with storage phosphor autoradiography (B) after intravenous administration of 18F-(N-methyl)benperidol to male Sprague–Dawley rat with highest accumulation in striata (1) and salivary glands (2). (A) Whole rat head. (B) Cerebrum. Outline of autoradiographic slice (rat’s cerebrum) was transferred to PET image.

 


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  		FIGURE 3. Striatal radioactivity concentration of 18F-(N-methyl)benperidol obtained with storage phosphor autoradiography plotted against radioactivity concentration measured with PET camera after decay, partial-volume, and spillover correction.

 




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