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Quantitative Analysis of Regional Motion and Thickening by Gated Myocardial Perfusion SPECT: Normal Heterogeneity and Criteria for Abnormality

Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles; CSMC Burns and Allen Research Institute, Los Angeles; and Departments of Medicine and Radiological Sciences, University of California Los Angeles School of Medicine, Los Angeles, California

View larger version (16K): [in a new window]   FIGURE 1. Schematic representation of 20-segment model of left ventricle.

View larger version (15K): [in a new window]   FIGURE 2. Plot of normal motion and thickening (mean ± SEM) at 4 levels from apex to base.

View larger version (16K): [in a new window]   FIGURE 3. Circumferential variations in normal segmental motion at distal, mid, and basal ventricular levels.

View larger version (16K): [in a new window]   FIGURE 4. Circumferential variations in normal segmental thickening at distal, mid, and basal ventricular levels.

View larger version (22K): [in a new window]   FIGURE 5. Thresholds (number of SDs below reference value) for defining motion (A) and thickening (B) abnormalities.

View larger version (13K): [in a new window]   FIGURE 6. Overall sensitivity (black bars) and specificity (white bars) in detecting segmental motion and thickening abnormalities by quantitative algorithm in validation group.

View larger version (26K): [in a new window]   FIGURE 7. Segment-by-segment sensitivity (black bars) and specificity (white bars) in detecting motion (A) and thickening (B) abnormalities by quantitative algorithm in validation group.

View larger version (20K): [in a new window]   FIGURE 8. Correlation between quantitative versus visual summed motion score (A) and summed thickening score (B). Solid line indicates linear fit and dashed line indicates line of identity.