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Is ^99mTc-Sestamibi Scintimammography Complementary to Conventional Mammography for Detecting Breast Cancer in Patients with Palpable Masses?

Nuclear Medicine Center, Medical Oncology Department, Medicine Department, and Mammography Unit of Radiology Department, University of Uruguay, Montevideo, Uruguay; Nuclear Medicine Center, University of Chile, Santiago, Chile; Nuclear Medicine Department, Istanbul University, Istanbul, Turkey; Nuclear Medicine Department, National Cancer Institute, Bogotá, Colombia; Department of Nuclear Medicine, Ocean Road Cancer Institute, Dar es Salaam, Tanzania; Nuclear Medicine Department, Peruvian Institute of Nuclear Energy, Lima, Peru; Nuclear Medicine Section, Department of Human Health, International Atomic Energy Agency, Vienna, Austria; and Nuclear Medicine Department, Indraprastha Apollo Hospitals, New Delhi, India

View larger version (113K): [in a new window]   FIGURE 1. A 46-y-old premenopausal patient with palpable lesion of right breast. (A) Craniocaudal mammogram shows fibroglandular tissue without significant abnormalities (BI-RADS 1). (B) SM shows focal tracer accumulation in breast (long arrow) and axillary region (short arrow). Histopathologic examination found invasive ductal carcinoma, with 2 metastatic lymph nodes of 16 examined.

View larger version (115K): [in a new window]   FIGURE 2. A 42-y-old patient with palpable lesion of left breast. (A) Mammogram shows high radiologic density with no suggestive abnormalities (BI-RADS 1). (B) Left lateral prone SM shows tumor uptake (arrow) corresponding to invasive ductal carcinoma.

View larger version (21K): [in a new window]   FIGURE 3. Flow chart shows diagnostic role of joint use of mammography and SM in evaluation of patients with palpable breast lesions.