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FDG Uptake and Glucose Transporter Subtype Expressions in Experimental Tumor and Inflammation Models

Departments of Nuclear Medicine, Tracer Kinetics, Pathological Oncology, and Microbiology, Graduate School of Medicine, Hokkaido University, Sapporo; Department of Radiology, Nikko Memorial Hospital, Hokkaido; and Department of Radiology, Jichi Medical School, Tochigi, Japan

View larger version (134K): [in a new window]   FIGURE 1. Staining with anti-GLUT-1 (A) and anti-GLUT-3 (B) antibodies in tumor tissue and staining with anti-GLUT-1 (C) and anti-GLUT-3 (D) antibodies in inflammatory tissue. Significant amounts of GLUT-1 and GLUT-3 are expressed in tumor and inflammation models. (x200)

View larger version (19K): [in a new window]   FIGURE 2. Immunohistochemical grading in inflammatory and tumor tissues. Percentage of positively stained cells and intensity of GLUT have been visually graded and assessed by semiquantitative immunohistochemical grading performed by calculating product of intensity and percentage positive. Expression levels of GLUT-1 and GLUT-3 are significantly higher than those of GLUT-2, GLUT-4, and GLUT-5 in inflammatory and tumor tissues (*P < 0.0001). GLUT-1 expression level is significantly higher in tumor tissue than that in inflammatory tissue (P < 0.05). S.A. = S. aureus.