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High-Level Production of {alpha}-Particle–Emitting 211At and Preparation of 211At-Labeled Antibodies for Clinical Use

Michael R. Zalutsky, Xiao-Guang Zhao, Kevin L. Alston and Darell Bigner

Departments of Radiology and Pathology, Duke University Medical Center, Durham, North Carolina



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  		FIGURE 1. The distillation apparatus used for isolation of 211At from bismuth cyclotron target. (1) argon cylinder, (2) argon gas regulator, (3) gas filter, (4) inlet flow meter and valve, (5) Dewar containing dry ice, (6) ether trap, (7) Teflon valve, (8) tube furnace, (9) quartz inlet tube, (10) quartz still, (11) insulation ring, (12) aluminum-backed bismuth cyclotron target, (13) quartz support plate, (14) insulation ring, (15) glass still outlet tube, (16) radioactivity detector, (17) detector output to amplifier, counter, and strip chart recorder, (18) thermometer, (19) aluminum cooling block, (20) thermoelectric cooler, (21) outlet flow meter, and (22) charcoal filter trap.

 


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  		FIGURE 2. Plot of yield of SAB as function of radiation dose deposited in destannylation reaction mixture. No significant correlation was observed (r2 = 0.05).

 


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  		FIGURE 3. Size-exclusion HPLC profile of 211At-labeled chimeric 81C6 mAb (211At-labeling run 2).

 


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  		FIGURE 4. Plot of immunoreactive fraction of 211At-labeled chimeric 81C6 antibody as function of radiation dose received by antibody. No significant correlation was observed (r2 = 0.29).

 




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