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Measurement of Myocardial Blood Flow with PET Using 1-¹¹C-Acetate

Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York

View larger version (12K): [in a new window]   FIGURE 1. Compartmental model used to fit first 3 min of 11C-acetate tracer activity data. Model assumes that tracer enters freely exchangeable tissue pool at rate of F x E, where F is myocardial blood flow rate and E is extraction fraction for acetate. Tracer in freely exchangeable tissue pool either leaves that compartment and enters metabolically trapped pool with rate constant K1 or is washed out as function of blood flow.

View larger version (14K): [in a new window]   FIGURE 2. Blood (dashed line) and myocardial 11C-acetate tissue tracer activity data (symbols) along with model fits (solid line) from one subject. Parameter estimates are displayed along with their associated SEs derived from variance–covariance matrix of model parameters.

View larger version (12K): [in a new window]   FIGURE 3. Relationship between tissue FMM and echocardiographic measurements of left ventricular mass. Echocardiographic mass measurements were used to provide regression-based estimates of FMM for each subject to be used in analyzing 11C-acetate tissue tracer activity data.

View larger version (11K): [in a new window]   FIGURE 4. Histogram of average blood flow data obtained from measurements made with 15O-water and 11C-acetate using individual values of FMM. Both in healthy volunteers and in patients with left ventricular hypertrophy, use of subject-specific FMM yielded myocardial blood flow (MBF) estimates comparable with those obtained with 15O-water.

View larger version (13K): [in a new window]   FIGURE 5. Relationship between myocardial blood flow (MBF) measured with 11C-acetate and with 15O-water. 11C-acetate blood flow estimates were obtained using individualized values of FMM that were derived from echocardiographic mass measurements for each subject.

View larger version (12K): [in a new window]   FIGURE 6. Bland–Altman analysis showing degree of concordance between myocardial blood flow (MBF) measured with 11C-acetate and with 15O-water. Magnitude of bias was small (0.02 mL/g/min), with limits of agreement ranging from value of -0.22 mL/g/min to 0.27 mL/g/min. No trends in residuals were observed as function of increasing blood flow rate.