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An Evaluation of Myocardial Fatty Acid and Glucose Uptake Using PET with [¹⁸F]Fluoro-6-Thia-Heptadecanoic Acid and [¹⁸F]FDG in Patients with Congestive Heart Failure

William S. Middleton Memorial Veterans Hospital, Madison; Departments of Medical Physics and Medicine, University of Wisconsin-Madison, Madison, Wisconsin; and Department of Medical Physics, Duke University, Durham, North Carolina

View larger version (21K): [in a new window]   FIGURE 1. Schematic of imaging protocol. FDG was administered as bolus injection, whereas [18F]FTHA was administered as infusion.

View larger version (110K): [in a new window]   FIGURE 2. Representative short-axis reformatted summed [18F]FTHA (top) and FDG (bottom) images from same patient.

View larger version (27K): [in a new window]   FIGURE 3. Myocardial region-of-interest activity, total plasma activity, and metabolite-corrected time–activity curves after [18F]FTHA infusion.

View larger version (20K): [in a new window]   FIGURE 4. Example of graphic analysis plot for calculation of myocardial [18F]FTHA uptake rate Ki.

View larger version (17K): [in a new window]   FIGURE 5. (A) Comparison of Ki values for myocardial fatty acid uptake from this study with Ki values derived from two published studies of normal human heart using [18F]FTHA (14,15). (B) Comparison of myocardial free fatty acid uptake rates from this study with previous study using [18F]FTHA in normal human heart (15). (C) Comparison of myocardial glucose uptake rates from this study with previous study using FDG in normal human heart (17). *P < 0.01; **P < 0.006; #P < 0.0005; ##P < 0.05.