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Study of Quantitative Oral Radioactivity in Salivary Gland Scintigraphy and Determination of the Clinical Stage of Sjögren’s Syndrome

Department of Radiology, Faculty of Medicine, and Department of Oral Surgery and Clinical Laboratory, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan

View larger version (148K): [in a new window]   FIGURE 1. ROIs on scintigraphic image: area 7, oral cavity; areas 1 and 2, parotid glands; areas 4 and 5, submandibular glands; area 3, background for parotid glands; area 6, background for submandibular glands and oral cavity. Area numbers are adjacent to each ROI.

View larger version (13K): [in a new window]   FIGURE 2. Schematic presentation of time–activity curve for oral activity (A) and glandular activity (B) in normal pattern on salivary gland scintigraphy. (A) X = initial shoulder, representing vascular perfusion peak; Y = maximum activity point before stimulation; Z = maximum activity point after stimulation; x, y, and z = counts at X, Y, and Z, respectively. (B) A = initial shoulder, representing vascular perfusion peak or, if shoulder is unclear, at 1 min; B =maximum activity point before stimulation; C = stimulation point at 40 min; D = point at 41 min; E = minimum activity point after stimulation; a, b, c, d, and e = counts at A, B, C, D, and E, respectively.

View larger version (23K): [in a new window]   FIGURE 3. Actual time–activity curves of parotid glands (curves A and B), submandibular glands (curves C and D), and oral cavity (curve E) in 60-y-old healthy man. Parotid gland curves show monotonic uptake until stimulation; submandibular curves show spontaneous secretion, and oral cavity curve reflects resultant activity in mouth. Arrow marks lemon juice stimulation point.