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Prediction of the Usefulness of Combined Mammography and Scintimammography in Suspected Primary Breast Cancer Using ROC Curves

Departments of Nuclear Medicine and Radiology, Royal Free Hospital, London, United Kingdom

View larger version (115K): [in a new window]   FIGURE 1. A 39-y-old patient with extensive palpable and dense left breast mass reported as equivocal on conventional two-view XMM (A and B) and reported as cancer on 99mTc-MIBI SMM (C). Invasive ductal carcinoma, Bloom–Richardson grade 2 (20), was confirmed on histologic examination.

View larger version (101K): [in a new window]   FIGURE 2. A 30-y-old patient with palpable lesion reported as probably cancer (grade 4) on two-view XMM (A and B) but reported as normal on 99mTc-MIBI SMM (C). Histologic examination confirmed benign fibrocystic changes only.

View larger version (106K): [in a new window]   FIGURE 3. A 52-y-old patient with palpable lesion and right breast mass reported as normal (A and B); likewise, 99mTc-MIBI SMM (C) was reported as normal. Pathologic examination of excision biopsy specimen showed 20-mm grade 2 invasive ductal carcinoma.

View larger version (18K): [in a new window]   FIGURE 4. ROC curves for XMM, SMM, and combination of two techniques (SEQ).