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Somatostatin Receptor Scintigraphy and Gallium Scintigraphy in Patients with Sarcoidosis

Departments of Nuclear Medicine, Pneumology, and Rheumatology, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris; and Department of Internal Medicine, Hôpital Beaujon, Assistance Publique Hôpitaux de Paris, Paris, France

View larger version (106K): [in a new window]   FIGURE 1. Planar images of head and chest in patient with sarcoidosis 2 wk after corticosteroid therapy was stopped. (A) Gallium scintigraphy shows high uptake in nose, lacrimal glands, and salivary glands and mild uptake in skin lesion and in hilar and mediastinal lymph nodes. (B) SRS shows high uptake in nose; meningeal, lacrimal, and salivary glands; hilum and mediastinal area; lung; and two skin lesions, one on shoulder and one on neck.

View larger version (111K): [in a new window]   FIGURE 2. Coronal thoracic SPECT. (A) 67Ga images show mild uptake in skin lesion (arrow) and in hilar and mediastinal lymph nodes. (B) 111In-pentetreotide images show high uptake in hilar and mediastinal lymph nodes and in lung, skin lesions, and right axillary lymph node.

View larger version (110K): [in a new window]   FIGURE 3. Planar images of head and chest in patient with sarcoidosis treated by steroid therapy with decreasing doses (3 mg/day at time of scintigraphic evaluation). (A) Gallium scintigraphy shows only mildly increased uptake in hilar and mediastinal lymph nodes and in lung. (B) SRS shows high uptake with well-delineated lesions in hilar and mediastinal lymph nodes and in lung and reveals corticomeningeal and skull involvement, which was confirmed after SRS by cerebral MRI.