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Portal–Systemic Shunts Reduce Asialoglycoprotein Receptor Density in Rats

Liver Transplant Program, Department of Surgery, Burns and Allen Research Institute, Cedars-Sinai Medical Center and University of California, Los Angeles; and Department of Radiology, University of California, San Diego, La Jolla, California

View larger version (25K): [in a new window]   FIGURE 1. Liver enzymes and bilirubin were not significantly different in shunted and sham-operated rats. Top and bottom of each box delineate upper and lower quartile ranges, that is, points containing 25% of data points above and 25% of data points below median. Median is indicated by thicker horizontal line. Error bars are shown above or below each box. Dark circles are data points from individual rats. Alk Phos = alkaline phosphatase; ALT = alanine aminotransferase; AST = aspartate aminotransferase.

View larger version (26K): [in a new window]   FIGURE 2. Ammonia, glucose, liver, and body weights were significantly different in shunted and sham-operated rats. Top and bottom of each box delineate upper and lower quartile ranges, that is, points containing 25% of data points above and 25% of data points below median. Median is indicated by thicker horizontal line. Error bars are shown above or below each box. Dark circles are data points from individual rats. Asterisks indicate significant differences (P < 0.05).

View larger version (18K): [in a new window]   FIGURE 3. Liver time–activity data with model simulations from two representative studies: sham-operated rat and shunted rat. o of sham-operated rat was 0.286 ± 0.007 nmol/g; receptor concentration [R]o was 0.901 ± 0.021 µmol/L. Shunted rat had o of 0.018 ± 0.001 nmol/g and [R]o of 0.273 ± 0.001 mol/L. kcts = kilocounts.

View larger version (16K): [in a new window]   FIGURE 4. Representation of ASGP-R o for shunted and sham-operated rats. Top and bottom of each box delineate upper and lower quartile ranges, that is, points containing 25% of data points above and 25% of data points below median. Median is indicated by thicker horizontal line. Error bars are shown above or below each box. Dark circles are data points from individual rats. Asterisk indicates significant differences (P < 0.05).

View larger version (24K): [in a new window]   FIGURE 5. (A) Simulated changes in 99mTc-GSA liver–activity curve if hepatic blood flow is reduced by 20% (solid line) or 50% (dashed line). (B) Simulated changes in 99mTc-GSA liver–activity curve if receptor concentration is reduced by 20% (solid line) or 50% (dashed line). 99mTc-GSA liver time–activity data from sham-operated rat are indicated by circles. kcts = kilocounts.