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The Journal of Nuclear Medicine Vol. 41 No. 12 2051-2062
© 2000 by Society of Nuclear Medicine
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Nonuniform Transmission in Brain SPECT Using 201Tl, 153Gd, and 99mTc Static Line Sources: Anthropomorphic Dosimetry Studies and Influence on Brain Quantification

Koen Van Laere, Michel Koole, Tomi Kauppinen, Myriam Monsieurs, Luc Bouwens and Rudi Dierck

Division of Nuclear Medicine, Ghent University Hospital, Ghent; Medical Imaging and Signal Processing Department and Laboratory for Standard Dosimetry, Ghent University, Ghent, Belgium; and Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland


Figure 1
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  		FIGURE 1. Transaxial CT scans of head and neck portion of RANDO anthropomorphic phantom with sagittal projection view. TLD dosimeter places are indicated.

 

Figure 2
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  		FIGURE 2. Stray scatter profile along bed axis measured by open thermoluminescent dosimeters for 201Tl ({blacktriangleup}), 153Gd (•), and 99mTc ({blacksquare}) line sources in gamma camera. Constant value in field of view is assumed. Biexponential fits are given (dashed lines). Dose rate values are normalized to unit source strength. A reference man is schematized along horizontal axis.

 

Figure 3
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  		FIGURE 3. Box-and-whisker plot for Hoffman phantom activity semiquantification obtained in cerebellar, cortical, subcortical, and central regions for isotopes 201Tl, 153Gd, and 99mTc. Iterative (OSEM) and FBP reconstruction techniques are compared. For 99mTc FBP, simultaneous ECT–TCT (T1E2) was also compared with sequential ECT–TCT (T3E3).

 

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  		FIGURE 4. 99mTc-ECD perfusion scans for healthy volunteers with nonuniform (A) versus uniform transmission (B) at different levels parallel to commissural plane. (C) 153Gd transmission CT map.

 




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