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Marrow-Sparing Effects of ^117mSn(4+)Diethylenetriaminepentaacetic Acid for Radionuclide Therapy of Bone Cancer

Division of Radiation Research, Department of Radiology, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey; Medical Department, Brookhaven National Laboratory, Upton, New York; and Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida

View larger version (20K): [in this window] [in a new window]   FIGURE 1. Effective clearance of radioactivity from murine femoral bone (), bone marrow (), and muscle () after intravenous administration of 117mSn(4+)DTPA. Data are presented as percentage injected activity per gram (%IA/g) of tissue. Data from two independent experiments are plotted.

View larger version (20K): [in this window] [in a new window]   FIGURE 2. Extrapolated initial uptake of radioactivity in femoral bone as function of injected activity after intravenous administration of 117mSn(4+)DTPA. Uptake is linearly proportional to injected activity. Data for several independent experiments are denoted by different symbols.

View larger version (18K): [in this window] [in a new window]   FIGURE 3. Survival of GM-CFCs as function of time after injection of 117mSn(4+)DTPA. Data from two independent experiments are plotted (•, 5850 kBq; , 370 kBq). As in earlier studies, nadir falls on seventh day after injection (20,27). This is optimal day to assay GM-CFC survival.

View larger version (21K): [in this window] [in a new window]   FIGURE 4. Survival of GM-CFCs as function of extrapolated initial activity in femoral bone (lower abscissa) and injected activity (upper abscissa) after intravenous administration of 117mSn(4+)DTPA. Animals were killed on seventh day after injection, the optimal day for GM-CFC assay (Fig. 3). Data from several different experiments are indicated by different symbols.

View larger version (19K): [in this window] [in a new window]   FIGURE 5. Survival of GM-CFCs as function of initial dose rate (lower abscissa) and absorbed dose (upper abscissa). Mice were irradiated chronically with exponentially decreasing dose rates (dose-rate decrease half-time = 222 h) of external 137Cs -rays (26) and killed on seventh day after initiation of irradiation. Absorbed dose is calculated by integrating dose rate over 7-d irradiation period. Open and closed symbols represent data for two independent experiments.