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Nodal Staging of Lymphoma with Whole-Body PET: Comparison of [¹¹C]Methionine and FDG

Department of Oncology and Radiotherapy, Department of Radiology, and Turku PET Center, Turku University Central Hospital, Turku, Finland

View larger version (141K): [in this window] [in a new window]   FIGURE 1. WB PET images of 26-y-old man with stage IV HD (nodular sclerosis type) and untreated diabetes mellitus (blood glucose, 16.5 mmol/L at time of PET scanning). MET PET image (A) shows mediastinal lesions (arrow) that are not seen on FDG PET image (B). MET findings were also accordant with CT lesions in right axilla and distal part of sternum, which are not depicted in this coronal plane.

View larger version (92K): [in this window] [in a new window]   FIGURE 2. WB PET images of 51-y-old woman with stage IV low-grade NHL in whom CT, FDG, and MET PET were concordant in detection of nodal findings. In FDG images (A), 2 coronal slices show intense focal uptake in multiple lymph node regions both superior and inferior to diaphragm. (B) Coronal MET PET images show similarly intense focal uptake in multiple lymph node regions. Physiologic uptake pattern differs between FDG (e.g., urinary bladder) and MET (e.g., liver, pancreas).

View larger version (109K): [in this window] [in a new window]   FIGURE 3. Coronal PET images of 50-y-old man with low-grade NHL (stage IV). FDG (A) and MET (B) images show similarly enhanced uptake in cervical, supraclavicular, axillary, abdominal, and inguinal regions.