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The Journal of Nuclear Medicine Vol. 41 No. 12 1941-1946
© 2000 by Society of Nuclear Medicine
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Three-Dimensional Color-Modulated Display of Myocardial SPECT Perfusion Distributions Accurately Assesses Coronary Artery Disease

Cesar A. Santana, Ernest V. Garcia, Johnathan P. Vansant, Elizabeth G. Krawczynska, Russell D. Folks, C. David Cooke and Tracy L. Faber

Radiology Department, Emory University Hospital, Atlanta, Georgia


Figure 1
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FIGURE 1. Dual-isotope (sestamibi and thallium) SPECT study of 51-y-old man with class 4 angina pectoris and hyperlipidemia. Coronary angiography showed 70% lesion in LAD, 80% lesion in first marginal area in LCX territory, 60% lesion in second marginal area in LCX territory, and 60% lesion in RCA and posterior descending artery. Patient exercised on treadmill for 8 min and had 1-mm ST-T depression. He reached 93% of predicted heart rate. Three months after myocardial perfusion imaging and cardiac catheterization, patient underwent coronary bypass surgery. Findings of tomograms (A) and 2-dimensional color modulated images (B) were interpreted as abnormal, with hypoperfused anterior, lateral, and inferior walls.

 

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FIGURE 2. Comparison of ROC for visual interpretation of slices versus 3-dimensional (3D) color-modulated displays showing no statistically significant differences between techniques. Points plotted represent input to Rockit program (University of Chicago) (15) that generated corresponding ROC curves and related statistics. Bars represent uncertainty of measurements in terms of 1 SD.

 

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FIGURE 3. Comparison of ROC results obtained from visual interpretation by experts of tomographic slices versus 3-dimensional (3D) color-modulated surface displays. These results are reported for overall localization to all 3 vascular territories (all vessels) and for LAD, LCX, and RCA vascular territories. No statistically significant differences were detected.

 





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