HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Murthy, K. Articles by Gagnon, J. H. Search for Related Content PubMed Articles by Murthy, K. Articles by Gagnon, J. H.

Results of Preliminary Clinical Trials of the Positron Emission Mammography System PEM-I: A Dedicated Breast Imaging System Producing Glucose Metabolic Images Using FDG

Montreal Neurological Institute, Medical Physics Unit, and Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada

View larger version (122K): [in this window] [in a new window]   FIGURE 1. Photograph of PEM-1 system installed in mammography unit at Cedars' Breast Clinic. Lower detector is housed in standard mammographic magnification table and positioned below breast. Upper detector is positioned above compression paddle.

View larger version (28K): [in this window] [in a new window]   FIGURE 2. Schematics showing position of PEM detectors during acquisition of mammogram (A) of breast and emission scan (B) of breast. During mammogram, coregistration tool occupies position of PEM detectors. During emission scan, detectors replace coregistration tool.

View larger version (28K): [in this window] [in a new window]   FIGURE 3. Basic principles of data acquisition and limited-angle backprojection used in formation of PEM images. Planar PEM images are displayed in sets of 7 frames, with leftmost frame corresponding to slice closest to upper detector.

View larger version (24K): [in this window] [in a new window]   FIGURE 4. Formation of 7 planar images. Volume of breast between detectors is divided into 7 equal slices. Point of interaction of LOR with 7 planes is used to localize event in that plane. Final image set consists of 7 frames, each of which corresponds to 1 slice.

View larger version (49K): [in this window] [in a new window]   FIGURE 5. Typical set of true-positive PEM-I images, with upper row showing 7 emission images from breast with suggestive findings and lower row showing images from contralateral breast. Each image frame represents 1 slice through breast, with upper edge of frame corresponding to region of breast closest to chest wall and leftmost frame corresponding to image plane closest to upper detector. Localized region of preferential FDG uptake is visible in upper set of images. Pathologic evaluation of excised mass revealed infiltrating and intraductal carcinoma (2.5 x 2.2 x 2.2 cm, histologic grade 3 [Bloom Richardson], nuclear grade III).

View larger version (122K): [in this window] [in a new window]   FIGURE 6. True-positive PEM image in pseudocolor overlaid on its corresponding mammogram in gray scale. Outline of coregistration tool, which appears white on mammogram (shown in green here), is used to scale best-focused PEM image. That image is then overlaid on mammogram. Top of image corresponds to region closest to chest wall of subject; left side of image corresponds to left side of imaged breast.