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Quantitative Comparison of Automatic and Interactive Methods for MRI–SPECT Image Registration of the Brain Based on 3-Dimensional Calculation of Error

Departments of Diagnostic Radiology and Nuclear Medicine, Klinikum Innenstadt, University of Munich, Munich, Germany

View larger version (23K): [in this window] [in a new window]   FIGURE 1. Definition and orientation of axes for translations (X, Y, and Z) and rotations (XY, XZ, and YZ).

View larger version (152K): [in this window] [in a new window]   FIGURE 2. Given 2 brain positions, one defined by the gold standard and the other by a single registration trial, registration error for this trial is calculated as average distance between corresponding voxels X and Y.

View larger version (12K): [in this window] [in a new window]   FIGURE 3. Definition of gold standard Pm. Pm is defined as mean position resulting from different positions P1–P5 representing repeated registrations.

View larger version (108K): [in this window] [in a new window]   FIGURE 4. User interface for interactive matching. Gray-scale MR images are overlaid with color-coded SPECT images in each of 4 view ports. SPECT image is moved (translation and rotation) in relation to MR image until a best fit is achieved in all view ports.