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Histochemical Correlates of ¹⁵O-Water–Perfusable Tissue Fraction in Experimental Canine Studies of Old Myocardial Infarction

National Cardiovascular Center—Research Institute, Osaka; Research Institute for Brain and Blood Vessels, Akita; Shimadzu Corporation, Kyoto, Japan; MRC Cyclotron Unit, Hammersmith Hospital, London, United Kingdom; and Royal Prince Alfred Hospital, Sydney, Australia

View larger version (100K): [in this window] [in a new window]   FIGURE 1. Comparison of PTF images obtained using 6-min dynamic images and weighted integration method (A) and those obtained using equilibrium method (B). Images represent 3 different transaxial slices. Small defect in anterior wall corresponds to myocardial infarction. Note that same color scale is used for the 2 functional images.

View larger version (22K): [in this window] [in a new window]   FIGURE 2. Comparison of PTF values obtained using 6-min dynamic images by weighted integration (WI) method with those obtained using equilibrium method. Symbols correspond to septum and to walls that included myocardial infarction. Data were obtained from all 12 dogs. No significant difference occurred between the 2 methods in septum or lateral wall, but PTF values were slightly but significantly greater in anterior wall for equilibrium method than for dynamic method (0.332 ± 0.111 g/mL and 0.305 ± 0.113 g/mL, respectively; P < 0.05).

View larger version (80K): [in this window] [in a new window]   FIGURE 3. Representative MBFt and PTF images together with corresponding histochemical-stained (EM and HE) cross-section of myocardium. Ant = anterior wall; Lat = lateral wall; Sep = septum.

View larger version (23K): [in this window] [in a new window]   FIGURE 4. Comparisons of defect surface area identified on PTF and MBFt images and morphometric estimates of surface area of infarcted myocardium derived from myocardial slices stained with EM. Data were obtained from all dog studies (n = 12).

View larger version (87K): [in this window] [in a new window]   FIGURE 5. Comparison of PTF and Dev images together with histochemical-stained slices (TTC, EM, and HE). Data were obtained from open-chest experiment in which slice position for histochemical analysis was carefully determined on scanner bed by marking PET tomographic slice position directly on myocardium guided by laser beams. Arrows point to nontransmural infarction.

View larger version (25K): [in this window] [in a new window]   FIGURE 6. Comparison of PTI values with fraction of histochemically normal tissue for whole midventricular slice. Correlation was significant (y = 0.073 + 0.963x), although PTI values were significantly greater than results from morphologic estimates (0.87 ± 0.09 and 0.83 ± 0.08, respectively; P < 0.01).