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Peptide Receptor Imaging and Therapy*

Department of Nuclear Medicine, University Hospital Rotterdam, Rotterdam; and Erasmus University, Rotterdam, The Netherlands

View larger version (27K): [in this window] [in a new window]   FIGURE 1. Example of additional information obtained with SPECT imaging (A and B) compared with planar abdominal imaging (C and D). With planar imaging, there is homogeneous liver activity; there is some breast attenuation on anterior image (C). Increased activity in cranial part of liver can be seen in A and especially B. Note gallbladder activity in B.

View larger version (126K): [in this window] [in a new window]   FIGURE 2. Normal SRI scan, 24 h after injection. Left lateral anterior, posterior, and right lateral images of head and neck (A), and anterior (B) and posterior (C) spot views. Note faint uptake in pituitary and thyroid glands. Normal visualization of kidneys, liver, spleen, and bowel and bladder activity.

View larger version (132K): [in this window] [in a new window]   FIGURE 3. Lateral views of the head (A), anterior and posterior view of thorax (B), and anterior and posterior view of abdomen (C) 24 h after injection in patient with metastatic insulinoma. Note clear uptake in multiple liver metastases and in left supraclavicular region; also, note faint breast uptake that occurs in approximately 15% of female patients.

View larger version (142K): [in this window] [in a new window]   FIGURE 4. Visualization of neuroendocrine pancreatic tumor with liver metastases in patient with multiple endocrine neoplasia syndrome.

View larger version (114K): [in this window] [in a new window]   FIGURE 5. Images of patient with multiple liver metastases of neuroendocrine tumor. Note intense uptake in small lesion in midline and multiple lesions in liver with central necrosis. As in Figure 3, there is faint breast uptake.

View larger version (58K): [in this window] [in a new window]   FIGURE 6. Anterior (A) and posterior (B) thoracic images in patient with remnant of Hürthle-cell carcinoma of thyroid. There is clear visualization of tumor and activity in liver, spleen, and kidneys. Note gallbladder visualization on anterior image.

View larger version (77K): [in this window] [in a new window]   FIGURE 7. Bone scan (A) and SRI (B; lower 2 images run from pelvis to knees) in patient with Erdheim-Chester disease, a granulomatous disease related to histiocytosis. Skeletal disease involvement and soft-tissue chest involvement are visualized with SRI.

View larger version (139K): [in this window] [in a new window]   FIGURE 8. Lateral (A) and anterior and posterior views of head (B) and thorax (C) 24 h after injection in patient with sarcoidosis. There is typical pattern of uptake, resembling gallium scan, with uptake in salivary and lacrimal glands and nose, and in chest mediastinal and bihilar pathology is seen.