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Equilibration of 6-[¹⁸F]Fluoro-L-m-Tyrosine Between Plasma and Erythrocytes

Theoretical Biology, Institute for Advanced Study, Princeton, New Jersey; Department of Physics and Astronomy, McMaster University, Hamilton, Ontario; and Department of Nuclear Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada

View larger version (33K): [in this window] [in a new window]   FIGURE 1. Time course of measured R(t) for FmT (A, ) and FHPAA (B, ). Solid lines show best fit to these data by most appropriate model, as determined using F statistic. Most appropriate model for FmT data was determined to be 1-parameter compartmental model described by Equation 3; for FHPAA appropriate model was 2-parameter compartmental model (Eq. 5).

View larger version (18K): [in this window] [in a new window]   FIGURE 2. Time course of R(t) for each of 4 tracers. Population mean values of best-fit parameters were used to calculate R(t) for FDG (dotted line), RIHSA (dotted-dashed line), FmT (solid line), and FHPAA (dashed line). Error bars show mean value ± 1 SD of Re for FDG, RIHSA, and FHPAA; Re is constrained to equal 1 by model used for FmT data. Re was not significantly different from 1 for FDG and not significantly different from 0 for RIHSA. Inset replots equilibration of FHPAA (dashed line), with population mean of metabolite fraction (dotted line) from in vivo FmT studies. Note different time scale.