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Pulmonary Distribution and Kinetics of Inhaled [¹¹C]Triamcinolone Acetonide

Division of Radiology, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio; and Medical Affairs, Rhône Poulenc Rorer Pharmaceuticals Inc., Collegeville, Pennsylvania

View larger version (50K): [in this window] [in a new window]   FIGURE 1. Intermediate step in lung region definition. Single-slice lung region boundary, as defined by semiautomatic region-growing method, is shown (A and B), with 3-dimensional region formed by combining regions defined on individual slices (C).

View larger version (73K): [in this window] [in a new window]   FIGURE 2. Example of 3-dimensional regions of interest created for 1 scan. Brown = whole lung; blue = trachea and main bronchi combined; green = nontarget region, mouth, and throat.

View larger version (117K): [in this window] [in a new window]   FIGURE 3. The GUI used for image registration. Shown are transaxial, sagittal, and coronal views (left to right) of selected slices from image volume sets of (top to bottom) CT, PET transmission, and pseudo–color overlay of the 2 (CT in red, PET in green). Yellow crosshairs show locations on each slice of 2 orthogonal slices. Slide bar controls (not shown) for each plane allow selection of slice displayed and control rotation and translation of PET data within its volume.

View larger version (68K): [in this window] [in a new window]   FIGURE 4. PET images of TAA deposition without (A) and with (B) use of spacer during inhalation.

View larger version (21K): [in this window] [in a new window]   FIGURE 5. Time–dose curves from summary regions. Deposition in high-dose regions combined by function is shown versus time. Data points are placed at beginning of relevant scan period. Swallowed dose (abdomen and esophagus), dose in entire airway (trachea to outer lung), and dose in target tissues (bronchi to outer lung) are shown for deposition with use of spacer and without spacer.

View larger version (21K): [in this window] [in a new window]   FIGURE 6. Target regions shown as in Figure 5. Deposition in bronchus, mid lung, outer lung, and trachea is shown with use of spacer and without spacer.