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Ventilation-Perfusion Relationship in Humans Measured by Scintillation Scanning

University of Miami School of Medicine, Miami, Florida

ABSTRACT

A method for determining regional pulmonary ventilation-perfusion relationships during the "steady state" by quantitative scintillation scanning is presented using a 10-crystal rectilinear scanner. Regional air distribution is measured by the rates of washin and washout of ¹³³Xe and perfusion is determined immediately thereafter using ¹³¹I-labeled macroaggregated human albumin. Data are accumulated and recorded on magnetic tape for computer analysis to obtain numerical presentation.

The method has proven valuable in the assessment of regional pulmonary function in normal subjects and patients with a variety of pulmonary diseases.