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A Simple Procedure for High-Efficiency Radioiodination of Proteins

Tufts University School of Medicine, Boston, Massachusetts

ABSTRACT

The iodine monochloride method of McFarlane has been adapted to permit labeling efficiencies of 70–90% for quantities of gamma globulin varying from 1 to 1,000 mg. The procedure is simple and rapid for radioiodinations at tracer levels; at high activity levels, hydrogen peroxide is first removed from the radioiodide solution by heat treatment at alkaline pH. There is no theoretical limit to the quantity of protein that can be iodinated at one time.