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Studies on Quantitation of the ⁵¹Cr-Erythrocyte Spleen-to-Liver Ratio

Yale University School of Medicine, New Haven, Connecticut

ABSTRACT

A reasonable first conceptual model of the splenic content of ⁵¹Cr following injection of labeled erythrocytes is presented. Analog-computer solutions of the equations are shown, and the model is found to be highly sensitive to the splenic exit rate constant. This rate constant is suggested as an additional indicator of splenic activity. Procedures are proposed for clinical estimation of the splenic exit rate constant (such as computer matching of the known data and solution of the equations at the point at which splenic radioactivity has peaked). Experiments on dogs indicated that the exit of splenic radioactivity is approximately first order with the quantity present when additional entry from the blood is negligible. It is suggested that such functional indications of activity be combined with estimates of organ weight obtained by scanning and by the allometric equations to yield indices of splenic and hepatic activity.