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Radioisotope Measurement of Brain Blood Turnover Time as a Clinical Index of Brain Circulation¹

Los Angeles, California

ABSTRACT

Brain blood pool transit times were studied in 534 subjects by an intravenous radioisotope technique utilizing external monitoring of brain passage of a bolus of non-diffusible radioactive indicator. This transit time (or pool turnover time) was used as an index of brain blood flow.

Brain blood pool transit times ranged between six and eleven seconds in healthy subjects with a general increase toward the long end of this range in advanced age.

Findings in hospitalized patients in a variety of disease categories are reported. Marked prolongation of transit times is seen in normotensive cerebrovascular disease, post-traumatic encephalopathy, and degenerative neurological disease. Moderate prolongation of brain transit time is seen in alcoholic encephalopathy, extracranial major arterial disease and brain tumor.

Slight prolongation of brain transit time is seen in post-traumatic seizures, transient cerebral ischemic disease and hypertensive cerebral infarction. A normal transit time is seen in idiopathic epilepsy, alcoholic epilepsy, non-cerebral neurological disease and hypertensive extracranial major arterial disease. Shortening of brain transit time is seen in arteriovenous malformation and the headache group.

There is generally a positive relationship between brain transit time and the arm-to-head circulation time. The significance of these data is discussed.

FOOTNOTES

¹ This work was in part supported by United States Public Health Service grant number NB-02575.

² Associate Chief, Neurology, Wadsworth Hospital, Veterans Administration Center, and Associate Professor of Medicine (Neurology) in Residence, University of California School of Medicine, Los Angeles, California.

³ Assistant Research Neurologist, University of California School of Medicine, Los Angeles, California.

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