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The Initial, Rapid-Phase Disappearance of Intravenous Radioinsulin in Diabetes¹

Hartford, Connecticut

ABSTRACT

The disappearance rate from the circulation of intravenously injected ¹³¹I insulin consists of an initial rapid phase for 20 minutes and a slower rate thereafter. A series of 44 patients is studied in an attempt to demonstrate significant differences between stable and labile diabetic patients in the half-time disappearance based on trichloracetic acid precipitated samples of serum taken at 10, 15 and 20 minutes after injection, as reported in another series (9).

Although in all but four of 30 patients who had received insulin prior to the test the T was definitely prolonged as compared with those patients who had not taken insulin, there was no difference in the values between the groups who were considered to be easily regulated on one dose of insulin a day and those more difficult to manage. Possible explanations for the discrepancy of results are offered.

There is an inverse relationship between the T values and the per cent of unbound insulin in the serum. There is an inverse relationship between the percent of unbound insulin in the serum and the per cent of total radioactivity that is in the gamma globulin fraction of the serum protein.

FOOTNOTES

¹ Presented at the Annual Scientific Meeting of the New England Chapter, Society of Nuclear Medicine, October 28, 1966, Boston, Massachusetts.