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Radioiodine Uptake Studies of the Human Fetal Thyroid^1,2,

Iowa City, Iowa

ABSTRACT

Thyroidal uptake of ¹³¹I in 36 human fetuses has been studied. There was no detectable uptake before the third month. From the third to the fourth month the uptake varied from 0.001 to 0.04% per gland with an average of 0.025, or approximately 1% per gram of thyroid. During the next month, the per cent per gland averaged 0.2 and the percent per gram of thyroid averaged almost two. The highest concentration was 5% per gram for the five to six month period. During this time, the uptake per gland was about 1%. Near term, the percent per gland increased to two, but the concentration was less than at the sixth month. The maximum concentration was about five times that of the adult thyroid, but this concentration is much lower than that found for the first few days after birth.

FOOTNOTES

¹ From the Radiation Research Laboratory, Departments of Obstetrics and Gynecology, and Internal Medicine, University of Iowa.

² Supported in part by grants from Div. of Biology and Medicine of U.S. Atomic Energy Commission.

³ Present address: Albert Einstein Medical Center, Philadelphia, Pa.