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A Sensitive Technique for Measuring Thyroidal Uptake of Iodine-131^1,2,

Cincinnati, Ohio

ABSTRACT

A unique, sensitive dual crystal system for thyroidal iodine uptake and kinetics utilizing photopeak to Compton scatter characteristics has been described. The results obtained with this system have been shown to correlate highly with those obtained with a standard thyroidal uptake system. The minimum detectable level for the dual crystal system placed inside the whole body counting room is 100 pCi (five-minute counting time for a 2.75 centimeter effective thyroid depth at the 95% C.L.). Because of the sensitivity of the system described, it offers a wide range of capabilities. One can markedly reduce the dose necessary for thyroidal uptakes, especially in children. Small quantities of radioiodine which might be present in the thyroid from environmental contamination can be quantitated. Radioiodine kinetics can be studied for extended periods of time with much smaller doses than used for the usual radioiodine uptake.

FOOTNOTES

¹ Supported in part by Public Health Service Training Grant 4TIRH36-04 from the Division of Radiological Health and by the Albertine O. Schoepf Research Fund of the College of Medicine, University of Cincinnati.

² Presented to the Thirteenth Annual Meeting of the Society of Nuclear Medicine, Philadelphia, Pennsylvania, June 1966.

³ From the Division of Radiological Health, U.S. Public Health Service.

⁴ From the Radioisotope Laboratory, University of Cincinnati College of Medicine.