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Measurement of Effective Renal Plasma Flow in Man by External Counting Methods¹

Boston, Massachusetts

ABSTRACT

A method has been devised to measure accurately the effective renal plasma flow (ERPF) in man by external counting over the head after a single injection of Orthoiodohippurate ¹³¹I. The external head curve is calibrated with two plasma samples drawn at three or five minutes and sixty minutes. The clearance is calculated from the slopes and intercepts of the components of the corrected curve as plotted on semilogarithmic graph paper. This method correlates closely with clearance calculated from continuous infusions of PAH (r=0.89). The previously reported correlation of plasma OIH clearances and PAH clearance is confirmed. External counting offers a means of determining renal function accurately without urine collection or multiple venepunctures.

FOOTNOTES

¹ This work was supported in part by the USPHS Grant number He-08260-02, the U. S. Army Medical Research and Development Command Grant number DA 49-193-MD-2457, and the John A. Hartford Foundation.

² Research Fellow in Medicine, Harvard Medical School, Assistant in Medicine and Radiology, Peter Bent Brigham Hospital. This work was done during the tenure of an Advanced Research Fellowship of the American Heart Association. Present address: Albert Einstein College of Medicine, N. Y., N. Y. 10461.

³ James Picker Foundation Advanced Fellow in Academic Radiology.

⁴ Associate Professor of Medicine, Harvard Medical School, Director, Cardiorenal Section, Peter Bent Brigham Hospital, Investigator, Howard Hughes Institute.