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Determination of in vivo Distribution Volumes in Man With Non-reactive Compounds¹

From the Department of Pathology, Ohio State University, Columbus, Ohio
The Biochemical Laboratory, Pineland Hospital and Training Center, Pownal, Maine

ABSTRACT

The apparent distribution volume of a-aminoisobutyric acid-1-C¹⁴ in patients with various forms of mental retardation is reported. The elimination of radioactivity of intravenously injected AIB-C¹⁴ from plasma and into urine was followed up to 10 days and, in the case of two patients, until no significant radioactivity could be demonstrated in urine. The size of the apparent distribution volume was dependent upon which of two methods of calculation were used. Some procedures are discussed for overcoming the difficulties in determining the distribution volume of AIB or other non-metabolizable compounds in vivo.

FOOTNOTES

¹ This investigation was supported by grant M-03961 from the National Institute of Mental Health and by grant HD-00774 from the National Institute of Human Development, P.H.S.