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The Journal of Nuclear Medicine Vol. 8 No. 2 110-116
© 1967 by Society of Nuclear Medicine
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Promotion of Radioisotope Excretion1,2,

William H. Strain3, Daniel T. Danahy3, Richard J. O'Reilly3, Martin R. Thomas3, Robert M. Wilson3 and Walter J. Pories, Major, USAF, MC4

Rochester, New York
Wright-Patterson A.F.B., Ohio

ABSTRACT

Manganese disodium EDTA and zinc disodium EDTA, two metal chelates widely used as agricultural products, have been shown to promote the excretion from rats of the corresponding radioisotopes manganese-54 and zinc-65. The effect is greatest the sooner the metal chelates are administered after injection of the radioisotopes. The principle of administering metal chelates to promote the excretion of radioisotopes corresponding to the metal of the chelate is broad. Further work will give greater understanding of the biological factors governing the metabolism of radioisotopes. This work will both increase the scope of nuclear medicine and provide treatments for nuclear accidents.

FOOTNOTES

1 From the Department of Radiology, School of Medicine and Dentistry, University of Rochester, Rochester, N. Y., and the Department of Surgery, USAF Hospital, Wright-Patterson AFB, Ohio. Presented at the 13th Annual Meeting, Society of Nuclear Medicine, Philadelphia, Pa., June 23, 1966.

2 This research was supported in part by grant RH 00042, Division of Radiological Health, Bureau of State Services, U.S. Public Health Service; by the Horatio H. Burtt Research Fund of the University of Rochester, and by a grant from the Aerospace Medical Division, under approval of the Surgeon General, U.S. Air Force. The contents of this paper reflect the authors' personal views and are not to be construed as a statement of official Air Force policy, The experiments were conducted according to the "Rules Regarding Animal Care," as established by The American Medical Association.

3 School of Medicine and Dentistry, University of Rochester, Rochester, N. Y.

4 USAF Hospital, Wright-Patterson AFB, Ohio.






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Copyright © 1967 by the Society of Nuclear Medicine.