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Non-Dialyzable Manganese, Copper and Sodium in Human Bile^1,2,

Hines, Illinois

ABSTRACT

Gallbladder bile was collected post-mortem from 36 adult male subjects, who were without history of biliary disorders and from eight patients undergoing cholecystectomy. T-tube bile collections were also made on six post-cholecystectomy patients. Collected samples were analyzed for protein and non-dialyzable content of copper, manganese and sodium.

The results indicated that greater concentrations of protein (1.8 ± 1.0 grams/100 ml), non-dialyzable copper (554 ± 329 µg/100 ml) and non-dialyzable sodium (5,104 ± 2,113 µg/100 ml) were present in the gallbladder bile of subjects without history of biliary disorders, than in subjects with biliary disorders (protein 1.4 ± 0.9 grams/100 ml; copper 341 ± 316 µg/100 ml; and sodium 1,689 ± 1,530 µg/100 ml).

The non-dialyzable manganese level in the non-biliary disease group of 36 subjects averaged 1.1 ± 0.6 µg/100 ml, while in the biliary disease group of eight subjects the manganese level was 2.1 ± 2.1 µg/100 ml.

FOOTNOTES

¹ Partially supported by U.S. Department of Health, Education and Welfare, National Institute of Health Grant No. RG-9045.

² From the Radioisotope Research Service, Veterans Administration Hospital, Hines, Illinois, and Loyola University Stritch School of Medicine, Chicago, Illinois.