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Effect of BAPN on Lipid Deposition in Rat Liver and Aorta. Studies Using 4-¹⁴C-Cholesterol

Baltimore, Maryland

ABSTRACT

1. The effect of BAPN on lipid deposition in the rat aorta was studied.

2. BAPN produced a marked reduction in chemical cholesterol deposition in the aorta, but this was not out of proportion to the reduction in liver chemical cholesterol or rat weight.

3. Studies with ¹⁴C-labeled cholesterol confirmed the above reduction.

4. ¹⁴C-cholesterol showed a much more marked reduction in the livers of the cholesterol-BAPN fed animals than in the aortas as compared with those fed the high cholesterol diet alone. Possible reasons for this are discussed.

5. There was little difference in the distribution among the various lipid fractions in the livers of the cholesterol-BAPN fed animals as compared with the cholesterol fed animals.

6. For the first time results of studies of lipid distribution in the aorta of rats on high cholesterol diets are presented.

7. These studies reveal, that as in most organs studied, cholesterol oleate predominates. However, unexpectedly, cholesterol palmitate is quite elevated in the aorta.

FOOTNOTES

¹ From the Medical and Radioisotope Services, Veterans Administration Hospital, Perry Point, Maryland, and Department of Radiological Services, John Hopkins Hospital, Baltimore, Maryland. The assistance of Ladymarie Wise and Carolyn K. Johnson, Dietetic Service, is gratefully acknowledged.