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The Effect of TSH on the Solitary Hyperfunctioning Thyroid Nodule¹

Philadelphia, Pennsylvania

ABSTRACT

1. A method is described for evaluating the iodine accumulation function of solitary thyroid nodules independent of the remainder of the gland.

2. The 24 hour uptake of ¹³¹I by the solitary hyperfunctioning thyroid nodule is not increased by 10 units of TSH.

3. Measurement of overall uptake following TSH is of limited value in demonstrating suppressed thyroid tissue in the presence of a hyperfunctioning nodule, but thyroid scanning and external counting will regularly indicate its presence.

4. TSH should never be administered prior to ¹³¹I therapy of a toxic, benign, solitary thyroid nodule (except for diagnostic purposes).

FOOTNOTES

¹ Presented at the 13th Annual Meeting, Society of Nuclear Medicine, Philadelphia, Pennsylvania, June 22–25, 1966.

² From the Division of Radiology (Department of Nuclear Medicine), Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141. Harold J. Isard, M.D., Chairman.