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The Journal of Nuclear Medicine Vol. 8 No. 10 735-739
© 1967 by Society of Nuclear Medicine
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Evaluation of Ascorbic Acid as an Adrenal Scanning Agent1,2,

Fred Mishkin, M.D. and Frank Castronovo, M.S.

Baltimore, Maryland

ABSTRACT

We injected guinea pigs with 1-14C labeled ascorbic acid intramuscularly and measured organ uptake of ascorbic acid 24 hours later to evaluate the possible use of ascorbic acid as an adrenal scanning agent. The organ uptake of the physiologically unaltered 14C compound was evaluated to learn whether or not concentration of ascorbic acid in the adrenal adequate for scanning could be achieved prior to attempts to label the compound with a gamma emitting nuclide, a procedure which might alter the biochemical properties of the compound. We found that the liver concentrated approximately 35 times more, the spleen 4 times more and the kidney 2.5 times more of the administered dose of ascorbic acid than did the adrenal. Giving ACTH one hour prior to the IM administration of the 14C ascorbic acid increased the adrenal uptake of ascorbic acid, but the uptake in the liver was still 12 times greater than that of the adrenal. ACTH given 3 hours prior to the IM administration of the ascorbic acid, loading with unlabeled ascorbic acid and an oral route of administration did not increase the adrenal concentration of the administered ascorbic acid. We conclude that ascorbic acid is unsuitable for an adrenal scanning agent.

FOOTNOTES

1 From the Radiological Sciences Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland.

2 This study supported by USPHS grant GM 10548.






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Copyright © 1967 by the Society of Nuclear Medicine.