HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by McCormack, K. R. Articles by Sheline, G. E. Search for Related Content PubMed PubMed Citation Articles by McCormack, K. R. Articles by Sheline, G. E.

Long-Term Studies of Solitary Autonomous Thyroid Nodules^1,2

San Francisco, California

ABSTRACT

Clinical evaluation, laboratory studies, radioiodine uptake studies and scintiscans were repeated on 53 patients whose initial study had shown the presence of a solitary hyperfunctioning thyroid nodule. The clinical management varied.Some patients received therapeutic radioiodine and others underwent surgical removal of the nodule or received exogenous thyroid hormone. Another group received no definitive therapy.

Hyperthyroidism developed in one patient from increased function within the nodule and in another from an apparently diffuse change in the residuum after lobectomy. In two patients who received prolonged exogenous thyroid hormone and in two who received no therapy, the nodule became smaller and lost its hyperfunction. No new hyperfunctioning nodule was noted during the follow-up period of up to nine and one-half years. In those patients who were hyperthyroid, elimination of hyperfunction by surgical removal, or by radioiodine treatment of the nodule, has controlled the hyperthyroidism to the present time. No thyroid carcinoma was found.

FOOTNOTES

¹ From the Nuclear Medicine Section, Department of Radiology, University of California School of Medicine, San Francisco, California. Supported by funds allocated by the Committee on Research, University of California School of Medicine.

² Presented at the 13th Annual Meeting of the Society of Nuclear Medicine, Philadelphia, Pennsylvania, June 22–25, 1966.