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Fate of Sodium Pertechnetate-Technetium-99m

Cairo, Egypt

ABSTRACT

The tissue distribution of sodium pertechnetate-^99mTc was studied in white mice. The highest levels of radioactivity were found in the stomach and kidneys, followed by the liver and lungs, and then the other organs. Furthermore, radioactivity per gram tissue of all the organs examined with the exception of the kidneys decreased markedly with time. The effective half-time for this disappearance of activity was shortest in the heart, lungs, testes and salivary glands, medium with the liver and spleen, and slowest for the stomach.

After pretreatment with potassium perchlorate, the disappearance of labelled pertechnetate from the circulation of dogs became slower and the tissue concentration of radioactivity in white mice was much lowered.

As regards the distribution of ^99mTc obtained from ⁹⁹Mo prepared by neutron bombardment, it proved to be similar to that described above, except for the much lower level of radioactivity in the kidneys and the slower disappearance of activity from the organs.

Reasons were suggested for the explanation of these findings.

FOOTNOTES

¹ Medical Unit and Division of Nuclear Medicine, Faculty of Medicine, Cairo University.

² Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University.

³ Nuclear Chemistry Department, A.E.E., U.A.R.