HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Akçay, M. M. Articles by Liu, C. K. Search for Related Content PubMed PubMed Citation Articles by Akçay, M. M. Articles by Liu, C. K.

Tracer Dilution Studies in Model Systems: Significance to Organ Blood Volume Measurements^1,2,

Torrance, California

ABSTRACT

Flow experiments using faucet water are carried out with rubber tube models of varying size. Iodine-131 is injected into the tubing, and dilution curves are registered externally at different detected volumes. The height of the dilution curve increases exponentially as detected volume is increased. The fractional increase in peak activity per ml detected volume is constant (0.053/ml) for all dilution curves registered over a wide range of detected and dilution volumes.

The application of this relationship to calculate detected volume from externally registered indicator dilution curves is discussed. Its clinical application to measurement of blood volume differences between paired organs and cardiac stroke volume is pointed out.

FOOTNOTES

¹ These studies were supported in part by Research Grant No. HE-08336-01, U.S. Public Health Service, and by Contract AT(04-1)-GEN-12 between the U.S. Atomic Commission and the University of California at Los Angeles.

² Division of Nuclear Medicine, Departments of Radiology and Medicine, Los Angeles County Harbour General Hospital, Torrance, California, and Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine and Departments of Radiology and Medicine, School of Medicine, University of California at Los Angeles.

³ Prof. of Physiology, University of Ankara Faculty of Medicine, Ankara, Turkey: Visiting Scientist, UCLA: Fellow, International Atomic Energy Agency, Vienna.