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Quantitation of Gastrointestinal Bleeding by Use of a Large Volume Scintillation Detector^2,3,

Chicago, Illinois

ABSTRACT

An essentially closed-system of stool collection and radioessay which involves only one specimen transfer has been coupled with sodium chromate-51 labeling of red-blood cells to provide a sensitive and accurate estimate of blood loss in feces.

After a patient's red-blood cells are labeled with ⁵¹Cr, his stools are collected into one gallon tins, mixed by external agitation, transferred to low potassium glass jars, and counted in a large volume scintillation counter.

Amounts of stool blood as small as 1 ml can be detected. This should provide a practical means of estimating the amount of blood lost in stools and provide a useful clinical diagnostic procedure.

FOOTNOTES

² From the Section of Hematology, Department of Medicine, Presbyterian-St, Luke’s Hospital and the Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois.

³ These investigations were supported by General Research Support Grant FR 05477 from the National Institutes of Health, U.S. Public Health Service.

¹ Present address: The Moutainside Hospital, Montclair, New Jersey.

² From the Section of Hematology, Department of Medicine, Presbyterian-St, Luke’s Hospital and the Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois.