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Cobalt-57 Labeled Vitamin B-12 Plasma Levels for the Differential Diagnosis of Macrocytic Anemias^1,5,

Baltimore, Maryland

Correspondence: ⁴ Reprint requests should he directed to Dr. Workman.

ABSTRACT

The results of studies of plasma levels and urinary excretion values following oral administrtion of tracer quantities of another cobalt isotope, the 270 day half-life cobalt-57, are presented. Tests were performed in 98 normal individuals and in 38 patients with Pernicious Anemia, without and with the addition of Intrinsic Factor Concentrate they remained lower than the normal values. Significant statistical separation between normals and Pernicious Anemia groups was demonstrated using the eight-hour plasma sample as a reference. Of the cobalt isotopes in general use, cobalt-57 delivers by far the smallest radiation dose to the liver and has the best counting efficiencies when standard hospital radioisotope laboratory equipment is used.

FOOTNOTES

¹ From the Department of Medicine, Radioisotope Laboratory, University of Maryland School of Medicine, Baltimore, Maryland.

⁵ Presented, in part, at the 7th annual meeting of the Society of Nuclear Medicine Estes Park, Colorado, June 27, 1960.

² Associate Professor of Medicine and Director, Radioisotope Laboratory.

³ Instructor in Medicine.