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Delineation of Active Marrow by Whole-Body Scanning with Radioactive Colloids¹

Oak Ridge, Tennessee

ABSTRACT

Radioisotopic scanning has been successfully applied to the evaluation of the hematopoietic organ. The objective is to delineate, with redioisotopic compounds, the size and location of functioning marrow, and to quantitate, if possible, the extent of abnormalities produced by marrow disorders or responses to various stresses. We have used intravenously administered radioactive colloids for this purpose. Improved isotopic labels and improved colloidal properties promise lower radiation exposures and more favorable marrow localizations. A whole-body scanner with a five-inch sodium iodide crystal and a 5:1 reduction scan of the patient's body has facilitated the procedure. Patterns of marrow alteration have been collected and analyzed in patients with acute leukemia, chronic leukemia, multiple myeloma, lymphoma, hemolytic anemia, polycythemia vera, and in patients with loval marrow lesions. Multiple factors involving instrumentation, interpretation of the scans.

FOOTNOTES

¹ From the Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee, under contract with the U. S. Atomic Energy Commission.