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The Journal of Nuclear Medicine Vol. 7 No. 7 556-563
© 1966 by Society of Nuclear Medicine
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Sequential Response of the Iodine-131 Hippuran Renogram in Renal Homotransplantation7

Alton R. Sharpe, Jr.1,6,, E. Richard King2, David M. Hume3, H. M. Lee4 and H. Myron Kauffman5

Richmond, Virginia

ABSTRACT

Four hundred and eighty-four serial renograms have been performed in 39 patients following renal transplantation.

Four distinctive renogram patterns have evolved from this study. Normal patterns immediately posttransplant were obtained in grafts from related donors and persistence of this pattern has been observed up to twenty-four months.

Determination of T 1/2 time in serial renogram tracings showing improvement or degeneration correlated well with conventional renal function studies.

Renograms showing continued prolongation of the T 1/2 time were characteristic of ultimate rejection.

Patterns suggestive of acute tubular necrosis, ureteral obstruction and arterial occlusion were of aid in the management of patients.

A delay in the T 1/2 time while not characteristic of rejection occurs early in the rejection phase, frequently precedes change in conventional renal studies, and is of value in predicting the need for additional immunosuppressive therapy.

FOOTNOTES

7 Supported in part by funds from the United States Public Health Service Grant No. HE 08203-01 Code 3823.

1 Associate Professor of Nuclear Medicine and Assistant Professor of Medicine.

2 Professor and Chairman, Department of Radiology.

3 Professor and Chariman, Department of Surgery.

4 Assistant Professor of Surgery.

5 Instructor in Surgery.

6 From Departments of Radiology, Section of Nuclear Medicine, and Surgery, Medical College of Virginia, Richmond, Virginia.






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Copyright © 1966 by the Society of Nuclear Medicine.