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A Study of the Metabolism of Fluorine-18 in Dogs and its Suitability for Bone Scanning^1,2,3,

Ann Arbor, Michigan

ABSTRACT

Twenty-five dog experiments were performed using orally and intravenously administered ¹⁸F as carrier free NaF. Bone scans and external point counting indicated that the uptake of ¹⁸F by bone reached a maximum within one hour and that scans of good quality could be achieved after that time. A rapid fall in blood radioactivity was found as well as rapid urinary excretion of ¹⁸F; 50% of the administered dose was found in the urine within six hours. Bone radioactivity usually was more than five fold that found in soft tissues (except kidney) as determined by well counting. Autoradiographs revealed nonhomogenity of ¹⁸F distribution in bone; 0.12 rad/mC is the estimated radiation dose to bone using the usual methods of calculations.

FOOTNOTES

¹ From the Department of Internal Medicine (Nuclear Medicine) Orthopedic Surgery and Chemistry, University of Michigan, Ann Arbor, Michigan.

² This investigation was supported by Michigan Memorial Phoenix Project #289, NIH CA-5134-03 and the University of Michigan Cancer Research Institute #72.

³ This paper was presented in part at the Twelfth Annual Meeting of the Society of Nuclear Medicine, Ball Harbour, Florida, June 17–19, 1965.