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Determination of Glomerular Filtration Rate by Use of Single Injection of Iodine-131 Labelled Sodium Diatrizoate¹

New Orleans, La.

ABSTRACT

Thirty-four individual clearance determinations on a series of ten dogs showed that ¹³¹I Hypaque with a single injection technique gave the same values for clearance as inulin. The clearance values were over a wide range and showed no increasing discrepancy at the lower or higher clearance values. The technique may be useful also in a clinical situation in which one wishes to determine glomerular filtration rate without the use of constant infusion and give a more accurate determination than is available with the 24 hour creatinine clearance.

FOOTNOTES

¹ This research was supported in part by U. S. Public Health Grants CRT-5057 and HE-04659.

² Section of Urology, Department of Surgery, Tulane University School of Medicine, New Orleans, La.

³ Special Fellow, United States Public Health Service.