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Glucose Production Rates in Dogs Determined by Two Different Tracers and Tracer Methods

Toronto, Canada

ABSTRACT

The rate of endogenous glucose production was calculated in fasting conscious dogs utilizing data obtained simultaneously with two different tracers, (6-³H) glucose and glucose uniformly labeled with ¹⁴C, and by two methods, A and B. Method A utilized successive measured injections of tracer (quantity dilution), while in Method B the rate was calculated by rate dilution employing the primed infusion of the tracer at a constant rate.

Statistical analysis of the results demonstrated that both tracer methods yield equal rates for glucose production.

However, 6-³H glucose as a tracer yielded glucose production rates significantly higher than when ¹⁴C glucose was used as tracer. Since with Method A the use of ¹⁴C glucose had been shown to yield valid glucose production rates as eviscerated dogs, 6-³H glucose is rejected as a tracer for glucose transfer rate studies in dogs.

FOOTNOTES

¹ Department of Physiology, University of Toronto, Toronto, Canada.

² Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada.

³ Research fellow of the American Diabetes Association