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The Thyroid Uptake of Selenium-75-Selenomethionine: Effect of L-Thyroxine and Thyroid Stimulating Hormone³

Boston, Massachusetts

ABSTRACT

The thyroid uptake of selenium-75-selenomethionine was investigated in rats and in two patients with hyperparathyroidism. Thyroid hormone pretreatment resulted in a decrease in the thyroid uptake of this amino acid analogue which could be partially reversed in the rat by thyrotropin.

Radioactive assay of thyroid and parathyroid tissues in two patients with hyperparathyroidism, one of whom received thyroid hormone suppression, demonstrated an augmentation of the parathyroid: thyroid specific activity ratio by decreasing the thyroid uptake in the treated patient. The relevance of these observations to the regional distribution of selenium-75-selenomethionine in clinical parathyroid scintiscanning is presented.

FOOTNOTES

³ This project was supported by the U.S. AEC Contract AT(30-1)3442 under which this manuscript becomes Document NYO-3442-6.

¹ Advanced Fellow in Academic Radiology of the James Picker Foundation: National Academy of Sciences, National Research Council.

² From the Harvard Medical School Department of Radiology at the Peter Bent Brigham Hospital, Boston, Massachusetts.