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Departments of Radiology and Medicine, University of Colorado Medical Center, Denver, Colorado
ABSTRACT
The paper presents a set of simple and frequently useful equations for least squares analysis of a set of data points that fit a single exponential function is presented. They can be applied quickly using a calculator and table of logarithms without knowledge of advanced mathematics. We have found them useful in determining the half-time of disappearance and Y intercept which best fit the data in several tests performed routinely in nuclear medicine. Comparison reveals a surprising discrepancy between the half-times determined by this method and those obtained by semilogarithmic plotting. It is suggested that the least-squares method presented is more objective and probably superior.
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