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Renal Retention of Mercury-203-Neohydrin

San Francisco, California

ABSTRACT

1) A controlled experiment was performed on rats to test the hypothesis that previously administered stable mercurial diuretic reduces renal retention of ²⁰³Hg—neohydrin.

2) There was a three-fold reduction in the renal retention of ²⁰³Hg—neohydrin following previously administered diuretic doses of mercuhydrin.

3) Administration of mercuhydrin 1, 8 or 24 hours before ²⁰³Hg—neohydrin affected renal ²⁰³Hg retention to an equal degree.

4) The probability of these findings being transferable to man is discussed. Assuming this to be the case, pre-dosing with a diuretic dose of mercuhydrin (1–2 cc) should reduce renal cortical irradiation from ²⁰³Hg—neohydrin, 10 µC/kg, to approximately 24–27 rad. This is felt to be a tolerable and safe dose.

5) Organic mercurial diuretics, used on a one-time basis, are considered quite safe and essentially free of risk.

FOOTNOTES

¹ Division of Radiation Therapy, Section of Radioisotopes University of Rochester School of Medicine and Dentistry, Rochester, New York.

² Present Address: Claire Zellerbach Saroni Memorial Tumor Institute, Mt. Zion Hospital, 1600 Divisadero Street, San Francisco, California